This web page was produced as an assignment for Gen677 at UW-Madison Spring 2012.
Gene ontology
Gene ontology includes the biological processes, cellular components, and molecular functions of a particular gene. Below is information on the ontology of the human ITGAM gene obtained from AmiGO, Locate, The Gene Ontology, and UniProt. These databases rely on information from primary literature.
predominantly expressed in monocytes and granulocytes
Subcellular localization
plasma membrane single-pass type I membrane protein
Neighborhood for the alphaM-beta2 integrin (Itgam-Itgb2) complex
Analysis
Using AmiGO, Locate, The Gene Ontology, and UniProt, I was able to search gene ontology databases to find ITGAM's role in biological processes, cellular components, and molecular functions and to determine its tissue specificity and subcellular localization. ITGAM is a single-pass type1 membrane protein of monocytes and granuocytes. ITGAM SNPs likely alter ITGAM's normal roles in blood coagulation, cell adhesion, integrin-mediated signaling pathway, and/or leukocyte migration.